Unique 7-digit amino acid sequence is similar to Japanese postal codes
Unique 7-digit amino acid sequence is similar to Japanese postal codes

Biozipcode (Cell-Targeting Technology)

Developing an innovative system to target and deliver drugs to specific cells in the body. This system uses a unique 7-digit amino acid sequence, similar to Japanese postal codes, to deliver drugs only to the target cells. This reduces the risk of side effects and allows the drug to act precisely where needed.

Building the Next-Generation Drug Delivery System

Biozipcode

Developing a groundbreaking drug delivery system that targets specific cells in the body. This system uses a unique 7-digit amino acid sequence that functions as a “Biozipcode” in the body, delivering drugs accurately to cells needing treatment. This minimizes the impact on non-target cells and significantly reduces the risk of side effects. With approximately 1 billion possible codes derived from 20 amino acids, it offers a wide range of options to target various cell types.

Building the Next-Generation Drug Delivery System
Building the Next-Generation Drug Delivery System

Identification of Specific Codes Using Phage Display Technology

Phage Display Technology

Utilizing phage display technology in our unique drug delivery system to identify specific amino acid sequences that bind only to target cells. Using a phage library with 7-digit amino acid sequences, we perform subtractions on various non-target cells and then select phages that bind specifically to target cells. Repeating this process identifies amino acid sequences that act with high precision, enabling targeted drug delivery.

7-digit amino acid sequences
7-digit amino acid sequences

Bioadaptive Nano-Drone Technology

Cell-Targeting

Using Biozipcode technology, it functions like nanodrones in the body, directly delivering drugs to cells needing treatment. This method identifies specific sequences that do not interact with any cells in the body, making it possible to target difficult-to-treat cells like cancer stem cells. Animal experiments with mice and monkeys show cross-species commonality, raising expectations for human applications.

Bioadaptive Nano-Drone Technology

Beyond Molecular Targeting: Ultimate New Technology

Beyond Molecular Targeting: Ultimate New Technology

Development of Side Effect-Free Diabetes Cures

  • Directly acting on “diabetes stem cells,” the cause of diabetes.

Development of Side Effect-Free Cancer Treatments

  • Pain relief treatment targeting nerve cells.

  • Cancer treatments acting directly on cancer cells.

  • Biozipcode obtained for all types of cancer.

Cell-Targeting for Tissue Regeneration

  • Tissue engraftment without the need for transplantation or suturing.

  • Layered tissue regeneration progresses naturally, promoting wound healing without hypertrophic scars or keloids.

Why is It Possible to Develop Drugs Without Side Effects?

Using the new transport system “Biozipcode,” a cell-targeting technology that delivers drugs directly to specific target cells.

Molecular Targeted Drugs

  • Target specific molecules or proteins.

  • Side effects occur if target molecules exist elsewhere.

  • Resistance develops with continuous use.

Cell-Targeted Drugs

  • Target specific “cells” only.

  • No side effects as they do not bind to non-target cells.

  • Resistance is less likely as they do not act elsewhere.

Discovery of the Cause of Diabetes

Discovery of Diabetes Stem Cells

Abnormal cells causing diabetes and its complications discovered in hematopoietic stem cells.

Complete Remission of Diabetes

Establishing a treatment method using “HDAC inhibitors” + “insulin.”

Diagnostic Drugs for Diabetes

Developing companion diagnostic drugs to diagnose diabetes based on the presence of diabetes stem cells in peripheral blood.

Biozipcode (Cell Targeting Technology)

Biozipcode (Cell Targeting Technology)

An innovative system for delivering drugs exclusively to specific cells in the body.

New Diabetes Cure Drugs

Development of entirely new diabetes cure drugs using Biozipcode.

Anti-Cancer Drugs with No Side Effects

Development of new drugs using Biozipcode and reuse of drugs previously unusable due to side effects.

Tissue Regeneration via Cell Targeting

Development of materials for tissue regeneration that can engraft onto tissues without needing transplants or sutures.